Sophie LECLERCQ [Short CV]  
FNRS Post-doctoral Researcher
0032 (0) 27 64 73 73

Research domains

  • Alcohol dependence
  • Gut-brain axis
  • Gut microbiota
  • Gut barrier
  • Blood-brain barrier
  • Inflammation
  • Metabolomics
  • Stress and PTSD
  • Antibiotics
  • Nutrition
  • Metabolism
  • Rodents models


  • Leclercq, S., Mian, F., Stanisz, A., Bindels, L., Cambier, E., Ben-Amram, H., Koren, O., Forsythe, P., and Bienenstock, J. (2017). Early life exposure to clinical dose penicillin induces long-term changes in gut microbiota, brain cytokines and behavior. Nature Communications, 4(8).15062.
  • De Timary, P., Stärkel, P., Delzenne, N.M., and Leclercq, S. (2017). A role for the peripheral immune system in the development of alcohol use disorders? Neuropharmacology, 1(122). 148-160.
  • Leclercq, S., De Timary, P., Delzenne, N.M., and Stärkel, P. (2017). The link between inflammation, bugs, the intestine and the brain in alcohol dependence. Translational Psychiatry,7(2). e1048.
  • Petit, G., Luminet, O., Cordovil de Sousa Uva, M., Monhoval, P., Leclercq, S., Spilliaert, Q., Zammit, F., Maurage, P., and De Timary, P. (2017). Gender Differences in Affects and Craving in Alcohol Dependence: A Study During Alcohol Detoxification. Alcoholism Clinical and Experimental Research, 41(2).421-431
  • Leclercq, S., Forsythe, P., and Bienenstock, J. (2016). Post-traumatic stress disorder: does the gut microbiota hold the key?. The Canadian Journal of Psychiatry, 61(4). 204-13.
  • de Timary, P.,Leclercq, S., Stärkel, P., & Delzenne, N. M. (2015). A Dysbiotic Subpopulation of Alcohol-Dependent Subjects. Gut microbes, 6(6). 388-391.
  • Leclercq, S., Matamoros, S., Cani, P. D., Neyrinck, A. M., Jamar, F., Stärkel, P., Windey, K., Tremaroli, V., Bäckhed, F., Verbeke, K., De Timary, P., Delzenne, N. M. (2014). Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity. Proceedings of the National Academy of Sciences, 111(42). E4485-E4493.
  • Leclercq, S., De Saeger, C., Delzenne, N., de Timary, P., & Stärkel, P. (2014). Role of Inflammatory Pathways, Blood Mononuclear Cells, and Gut-Derived Bacterial Products in Alcohol
    Dependence. Biological Psychiatry, 76(9). 725-733.
  • De Timary, P., Cani, P., Duchemin, J., Neyrinck, A.M., Gihousse, D., Laterre, P.F., Badaoui, A., Leclercq, S., Delzenne, N., & Starkel, P. (2012). The loss of metabolic control on alcohol drinking in heavy drinking, alcohol-dependent subjects. PLoS One, 7, e38682.
  • Leclercq, S., Cani, P., Neyrinck, A.M., Starkel, P., Jamar, F., Mikolajczak, M., Delzenne, N., & de Timary, P. (2012). Role of intestinal permeability and inflammation in the biological and behavioural control of alcohol dependent subjects. Brain, Behavior and Immunity, 26. 911-918.

Book chapter

  • Stärkel, P., Leclercq, S., Delzenne, N.M., de Timary, P. (2016). Chaptier 17 – Alcohol-Dependence and the Microbiota-Gut-Brain Axis. In N. Hyland & C. Stanton (Eds.). The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota (pp. 363-390). London, UK: Academic Press.